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|Title:||An inorganic approach to drug design: Novel inorganic nucleases†|
|Authors:||Cowan, J A|
|Abstract:||Copper aminoglycosides are demonstrated to be highly efficient cleavage catalysts for DNA and RNA targets. Such catalysts mediate both oxidative and hydrolytic pathways and their cleavage reactions display enzyme-like Michaelis-Menten kinetic behaviour. An unusual double-strand cleavage of DNA has been observed. Degradation of RNA viral motifs have been demonstrated in vitro, and the efficacy of such molecules against an in vivo target has also been established using a novel in vivo assay. Chemical mechanisms underlying the cleavage of RNA and DNA targets, recognition strategies, mechanisms of cellular delivery, and the design of ill vivo assays have been presented.|
|Appears in Collections:||IJC-A Vol.41A(01) [January 2002]|
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