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Title: Pre-formed iron-thiosemicarbazone chelates as ribonucleotide reductase inhibitors
Authors: Murugkar, Anupa
Padhye, Subhash
Vorobjeva, Lena
Issue Date: Aug-2003
Publisher: NISCAIR-CSIR, India
Abstract: Pre-formed iron(III) complexes of naphthoquinone thiosemicarbazone ligands, viz. 2-hydroxy-1,4-naphthoquinone-1-thiosemicarbazone (HNQTSC) and 2-thiosemicarbazido-1,4- naphthoquinone (TSCNQ) have been synthesized, characterized by various physical techniques and their potential for inhibition of ribonucleotide reductase (RDR) enzyme, crucial for DNA synthesis, has also been evaluated. It is observed that the pre-formed iron(III) complexes possess higher RDR inhibitory activity than the respective free ligands.
Page(s): 1861-1864
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.42A(08) [August 2003]

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