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|Title:||Thermodynamic parameters and stability constants of lanthanide(III) complexes of biologically active glutathione (GSH) and their chemical speciation|
|Authors:||Garg, B S|
Singh, B K
Kumar, Deo Nandan
Singh, P K
|Abstract:||The stability constants of lanthanide(III)
complexes of reduced glutathione (GSH) have been determined by potentiometric estimation
of [H+], in aqueous medium at different ionic strengths and at various
temperatures. The effect of dielectric constant on stability has been studied at
different percentage of solvent variations and at different solvent systems. The
and pL values have been calculated by the method of Irving and Rossotti. Computation
of stability constants are carried out on
an IBM compatible PC computer using the weighted least squares method. The values
of Smin are also evaluated. To visualise the nature of the equilibria
involving lanthanide(III) with glutathione, species distribution curves of complexes
have been plotted as a function of pH using the program SPE. The order
of stability constants is found to be|
La(III) < Pr(III) < Nd(III) < Gd(III) < Ce(III) < Sm(III) < Tb(III) < Dy(III < Ho(III) < Yb(III).
The thermodynamic parameters ΔG, ΔH and ΔS have been calculated at a fixed temperature of 25±0.5°C.
|Appears in Collections:||IJC-A Vol.42A(01) [January 2003]|
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