Please use this identifier to cite or link to this item:
|Title:||Rapid synthetic access to caged RNA|
|Keywords:||RNA;Caged RNA;Light-activatable RNA;Duplex destabilizing|
|Abstract:||Light-activatable RNA with “caged” nucleobases is a versatile tool for light-control of RNA interference, riboswitch folding or miRNA or ribozyme action. Till date the respective caged and protected phosphoramidites for the solid-phase RNA synthesis are obtained in lengthy syntheses. Herein we explore the use of convertible nucleoside residues for a rapid access to nucleobase-caged RNA. In these studies we have also prepared the first RNA with a caging group on an N2-position of a guanosine. The obtained caged sequences are compared in their duplex destabilizing ability via melting temperature measurements.|
|Appears in Collections:||IJC-A Vol.52A(08-09) [August-September 2013]|
Files in This Item:
|IJCA 52A(8-9) 1014-1018.pdf||90.25 kB||Adobe PDF||View/Open|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.