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Title: Base mediated 5-endo-dig cyclization of N-propargyl proline derivatives: A facile entry to pyrrolizidine scaffolds
Authors: Mahesh, Sriram
Pareek, Manish
Ramanjaneyulu, B T
Kaur, Gurpreet
Anand, R Vijaya
Keywords: Bicyclic compounds;Cyclization;5-endo-dig cyclization;Pyrrolizidine core;Propargyl amines
Issue Date: 3-Aug-2013
Abstract: A simple, base facilitated 5-endo-dig cyclization strategy has been exploited for the assembly of bicyclic core of pyrrolizidine alkaloids. This unprecedented protocol allows access to a diverse range of alkyl and aryl substituted pyrrolizidine scaffolds in moderate yields from readily available N-propargyl-L-proline ester derivatives under mild conditions. No catalyst or alkyne activator is required to effect this atom economical transformation.
Page(s): 1086-1092
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.52A(08-09) [August-September 2013]

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