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Title: QSAR studies on pyrrolo (2,1-d) (l,2,3,5)tetrazinones, a new class of azolotetrazines
Authors: Tripathi, Girish
Mishra, J P
Issue Date: Jul-2005
Publisher: NISCAIR-CSIR, India
IPC Code: lnt. C17 : C07D257/12
Abstract: Quantitative structure activity relationship (QSAR) has been performed on some pyrrolo (2,1-d) (l,2,3,5)tetrazinones series of antitumour drugs, using physico-chemical parameters such as equalized electronegativity, Xeq, molecular connectivity, IXb, and hydrophobicity, logP. Anticancer activity of these compounds in COLO-205 cancer cell has been found to correlate well with Xeq. The presence of -CONH2 function is found to be important for activity.
Page(s): 1398-1400
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.44A(07) [July 2005]

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