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|Title:||QSAR studies on pyrrolo (2,1-d) (l,2,3,5)tetrazinones, a new class of azolotetrazines|
Mishra, J P
|IPC Code:||lnt. C17 : C07D257/12|
|Abstract:||Quantitative structure activity relationship (QSAR) has been performed on some pyrrolo (2,1-d) (l,2,3,5)tetrazinones series of antitumour drugs, using physico-chemical parameters such as equalized electronegativity, Xeq, molecular connectivity, IXb, and hydrophobicity, logP. Anticancer activity of these compounds in COLO-205 cancer cell has been found to correlate well with Xeq. The presence of -CONH2 function is found to be important for activity.|
|Appears in Collections:||IJC-A Vol.44A(07) [July 2005]|
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