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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(09) [September 2008] >
| Title: | Studies on synthesis of unsymmetrical 2,2-bisbenzimidazole sulphides of pharmacological interest |
| Authors: | Dubey, P K
Naidu, A
Reddy, P V V Prasada
Kumar, N D Mahesh
Vineel, B George |
| Keywords: | Benzimidazole
Sulphides
TEA
TBAB
o-ethyl dithiocarbonate
TFA
Deoxy prazole |
| Issue Date: | Sep-2008 |
| Publisher: | CSIR |
| Abstract: | Condensation of 2-(-chloroethyl)benzimidazole 1 with benzimidazole-2-thiol 2 gives 2-(⍺-thioethyl-2-benzimidazolyl)benzimidazole 3. The latter can also be prepared by the reaction of 2-(⍺-thioethyl)benzimidazole 4 with 2-chlorobenzimidazole 5. Alternatively, 3 can also be synthesized by the independent condensation of o-phenylenediamine 7 respectively with 2-(s-⍺-ethyl-o-ethyldithio- carbonate)benzimidazole 6 and with 2-(⍺-thiopropionic acid) benzimidazole 8. The structures of all the compounds synthesized have been established on the basis of their spectroscopic data. |
| Page(s): | 1443-1446 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(09) [September 2008]
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