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Title: Studies on synthesis of unsymmetrical 2,2-bisbenzimidazole sulphides of pharmacological interest
Authors: Dubey, P K
Naidu, A
Reddy, P V V Prasada
Kumar, N D Mahesh
Vineel, B George
Keywords: Benzimidazole;Sulphides;TEA;TBAB;o-ethyl dithiocarbonate;TFA;Deoxy prazole
Issue Date: Sep-2008
Publisher: CSIR
Abstract: Condensation of 2-(-chloroethyl)benzimidazole 1 with benzimidazole-2-thiol 2 gives 2-(⍺-thioethyl-2-benzimidazolyl)benzimidazole 3. The latter can also be prepared by the reaction of 2-(⍺-thioethyl)benzimidazole 4 with 2-chlorobenzimidazole 5. Alternatively, 3 can also be synthesized by the independent condensation of o-phenylenediamine 7 respectively with 2-(s-⍺-ethyl-o-ethyldithio- carbonate)benzimidazole 6 and with 2-(⍺-thiopropionic acid) benzimidazole 8. The structures of all the compounds synthesized have been established on the basis of their spectroscopic data.
Page(s): 1443-1446
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(09) [September 2008]

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