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IJC-B Vol.47B(09) [September 2008] >


Title: Synthesis and antibacterial activity of 6-(5-phenyl-[1,3,4]thiadiazol-2-ylamino)-benzopyran-2-ones
Authors: Mayekar, Sagar A
Mulwad, Vinata V
Keywords: 6-Isothiocyanato coumarins
1,3,4-thiadiazole
Iodine
Pyridine
Acid hydrazide
Issue Date: Sep-2008
Publisher: CSIR
Abstract: 6-Amino coumarins 1a-c on treatment with carbon disulphide in presence of iodine in pyridine give 6-isothiocyanato coumarins 2a-c. Condensation of the acid hydrazide with 6-isothiocyanato coumarins has resulted in the formation of 2-benzoyl-N-(2-oxo-2H-benzopyran-6-yl)hydrazinecarbothioamides 3a-f which are cyclized to 6-(5-phenyl-[1,3,4]thiadiazol-2-ylamino)-benzopyran-2-ones 4a-f using Conc. H₂SO₄. The structures of the compounds 2a-c, 3a-f and 4a-f have been established on the basis of spectral and analytical data. All compounds have been screened for their antimicrobial activity and showed that the introduction of 1,3,4-thiadiazole show significant antibacterial activities.
Page(s): 1438-1442
ISSN: 0376-4699
Source:IJC-B Vol.47B(09) [September 2008]

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