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|Title:||Kinetics of oxidation of thymine by t-butoxyl radical — Protection and repair by caffeic acid|
|IPC Code:||Int. Cl.8 C07B33/00|
|Abstract:||The kinetics of oxidation of thymine and caffeic acid by t-BuO• has been studied by the photolysis of t-butyl hydroperoxide in presence of t-butanol. The rates and the quantum yields (φ) of oxidation of caffeic acid by t-BuO• radicals have been determined by varying concentrations of thymine. An increase in [thymine] has been found to decrease the rate of oxidation of caffeic acid suggesting that thymine and caffeic acid compete for t-BuO• radicals. From competition kinetics, the rate constant of t-BuO• - thymine reaction has been calculated to be 5.3×107 dm3 mol-1 s-1. The experimentally determined quantum yields (φexpt) and the calculated yields (φcal) of oxidation of caffeic acid, assuming that caffeic acid reacts only with t-BuO• radicals, suggest that caffeic acid not only protects thymine from t-BuO• radicals but also repairs thymine radicals formed by the reaction of t-BuO• radicals.|
|Appears in Collections:|| IJC-A Vol.45A(11) [November 2006]|
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