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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(09) [September 2008] >
| Title: | Titanocene(III) chloride mediated radical-induced synthesis of 3,4-disubstituted tetrahydrofurans: Formal synthesis of (±)-burseran and (±)-dehydrocubebin |
| Authors: | Jana, S
Paira, M
Roy, S C |
| Keywords: | Radical cyclization
Epoxides
Titanocene(III) chloride
Burseran
Dehydrocubebin |
| Issue Date: | Sep-2008 |
| Publisher: | CSIR |
| Abstract: | Synthesis of 3,4-disubstituted tetrahydrofurans has been achieved via radical cyclization of epoxides using titanocene(III) chloride (Cp₂TiCl) as a transition-metal radical source. The radical initiator (Cp₂TiCl) is generated in situ from commercially available titanocene dichloride (Cp₂TiCl₂) and zinc dust in THF under argon. Formal synthesis of two bioactive lignans, burseran and dehydrocubebin has also been accomplished through the radical technology. |
| Page(s): | 1430-1434 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(09) [September 2008]
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