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|Title:||Titanocene(III) chloride mediated radical-induced synthesis of 3,4-disubstituted tetrahydrofurans: Formal synthesis of (±)-burseran and (±)-dehydrocubebin|
Roy, S C
|Keywords:||Radical cyclization;Epoxides;Titanocene(III) chloride;Burseran;Dehydrocubebin|
|Abstract:||Synthesis of 3,4-disubstituted tetrahydrofurans has been achieved via radical cyclization of epoxides using titanocene(III) chloride (Cp₂TiCl) as a transition-metal radical source. The radical initiator (Cp₂TiCl) is generated in situ from commercially available titanocene dichloride (Cp₂TiCl₂) and zinc dust in THF under argon. Formal synthesis of two bioactive lignans, burseran and dehydrocubebin has also been accomplished through the radical technology.|
|Appears in Collections:||IJC-B Vol.47B(09) [September 2008]|
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