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Title: Solubility enhancement of rofecoxib in water in the presence of hydrobhilic polymers, surfactants, co-solvents, and small molecules at310.15K†
Authors: Desai, K H
Kulkarni, A R
Agnihotri, S A
Gudasi, K B
Aminabhavi, T M
Issue Date: Jul-2006
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8 A61 K
Abstract: Solubility enhancement of rofecoxib in water has been studied in presence of different conce ntrations of hydrophilic polymers like polyethylene glycol-4000 polyethylene glycol-6000 and polyvinylpyrrolidone (PVP- K30); surfactants like Span-20, Tween-80 and sodium lauryl sulfate (SLS): co-solvents like ethanol, propylene glycol and glycerol and small molecules like urea, mannitol and β-cyclodextrin at 310.15 K. Drug analysis has been carried out by HPLC method using UV detector at 254 nm. Drug solubility is greatly enhanced in the presence of PVP-K30, SLS, and ethanol. In the presence of small molecules, urea enhances the solubility much higher than mannitol or β-cyclodextrin.
Page(s): 1667-1669
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections: IJC-A Vol.45A(07) [July 2006]

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