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IJC-B Vol.47B(09) [September 2008] >

Title: Synthesis of biologically active 3-(2-oxo-2H-benzopyran-6-yl)-2- (-2-oxo-2H-benzopyran-6-ylimino)-thiazolidin-4-one and its derivatives
Authors: Mulwad, Vinata V
Mayekar, Sagar A
Keywords: 6-Amino coumarin
Aromatic aldehydes
Antibacterial activity
Issue Date: Sep-2008
Publisher: CSIR
Abstract: 1,3-Bis-(2-oxo-2H-benzopyran-6-yl)-thioureas 2a-c are obtained by refluxing 6-amino coumarins 1a-c and carbon disulphide in absolute alcohol which upon treatment with ethyl bromoacetate in the presence of sodium acetate in ethanol to give 3-(2-oxo-2H-benzopyran-6-yl)-2- (-2-oxo-2H-benzopyran-6-ylimino)- thiazolidin-4-ones 3a-c. The iminothiazolidinones 3a-c are treated with various substituted aromatic aldehydes to give 3-(2-oxo-2H-benzopyran-6-yl)-2- (-2-oxo-2H-benzopyran-6-ylimino)-5- [1-(3-trifluoromethyl-phenyl)-methylidene]- thiazolidin-4-ones 4a-l. Also the iminothiazolidinones 3a-c are treated with 2% HCl to give 3-(2-oxo-2H-benzopyran-6-yl)- thiazolidine-2,4-diones 5a-c. The structures of the compounds 2a-c, 3a-c, 4a-l and 5a-c have been established on the basis of spectral and analytical data. All compounds have been screened for their antimicrobial activity and have been found to exhibit significant antibacterial activities.
Page(s): 1397-1401
ISSN: 0376-4699
Source:IJC-B Vol.47B(09) [September 2008]

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