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Title: Preliminary antidiabetic studies on aqueous extract of Indigofera aspalathoides Vahl ex DC.
Authors: Rajendran, K
Shirwaikar, Annie
Srinivasan, K K
Keywords: Indigofera aspalathoides;Antidiabetic activity;Streptozotocin;Nicotinamide;Rats
Issue Date: Jun-2013
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2011.01) − A61K 36/00, A61P 3/10.
Abstract: Indigofera aspalathoides Vahl ex DC. (Fabaceae) is a low much branched and erect under-shrub. In Ayurveda and Siddha system of medicine the whole plant is used as bitter, antiseptic, disinfectant and for the treatment of diabetes. A short term study was under taken as a preliminary investigation to evaluate the antidiabetic effect of the aqueous extract by oral glucose tolerance test (OGTT), normoglycaemic and antihyperglycaemic activity in Streptozotocin (STZ)-nicotinamide induced Type-II diabetes rats. Two doses (250 and 500 mg/kg) of the aqueous extract dissolved in drinking water were administered to normal and experimental diabetic rats. Effect on glucose tolerance and hyperglycaemic studies showed only less remarkable decrease in blood glucose level at both dose levels as compared to Glibenclamide. Normoglycaemic study revealed significant percentage decrease in blood glucose level from the initial value in normal rats 20.58% and 26.55% (250 and 500 mg/kg, respectively) as compared to the control group 1.85 per cent.
Page(s): 146-150
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.4(2) [June 2013]

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