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Title: New Curcumin - Bioconjugate: Synthesis and DNA Binding
Authors: Kumar, Sanjay
Shukla, Vibha
Misra, Arvind
Tripathi, Snehlata
Misra, Krishna
Keywords: Curcumin;Glycine;Bioconjugate;Viscosity;Interaction;Groove binding
Issue Date: Apr-2002
Publisher: NISCAIR-CSIR, India
Abstract: A triglycyl derivative of curcumin, 1,7-bis (4-O-glycinoyl-3-methoxy phenyl)-1,6-heptadine-C-4-glycinoyl-3, 5-dione, was synthesized and characterized by UV, elemental analysis and 1H NMR. Interaction studies of curcumin and curcumin-bioconjugate with calf thymus DNA were carried out using UV -absorbance, gel electrophoresis and viscometric studies. Curcumin-bioconjugate was found to be A-T specific minOI- groove binder.
Page(s): 158-163
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections: IJBT Vol.01(2) [April 2002]

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