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Title: Apoptosis: An Overview
Authors: Anjum, Rana
Khar, Ashok
Keywords: Apoptosis;Programmed cell death mechanisms;Caspases;Mitochondria
Issue Date: Jan-2002
Publisher: NISCAIR-CSIR, India
Abstract: Apoptosis, a highly ordered cascade of enzymatic events that culminates in cell death and entails the autolytic degradation of cellular components, is characterized by blebbing of cell membrane, nuclear and cytoplasmic condensation, protein fragmentation and DNA degradation followed by rapid engulfment of cell corpses by neighbouring cells. It is essential for maintenance of cellular homeostasis and deregulation of this process leads to a spectrum of pathological manifestations. Caspases, which form the proteolytic network within the cell are among the critical components of cell death process. They bring about the cleavage and degradation of a number of proteins that result in cell demise. Mitochondria are regarded as the central control point in the execution of apoptosis. They release a potent cocktail of pro-apoptotic proteins into the cytosol, which results in the amplification of the death cascade, the most prominent one being cytochrome c. The mechanism by which cytochrome c is released into the cytosol is controversial but seems to be regulated by the Bcl-2 family of proteins.
Page(s): 58-72
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections: IJBT Vol.01(1) [January 2002]

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