Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/19810
Title: Quantitative structure activity relationship (QSAR) studies of some substituted benzenesulphonyl glutamines as tumour suppressors
Authors: Srikanth, K
Kumar, Ch. Anil
Goswami, Diptendu
De, A U
Jha, Tarun
Issue Date: Apr-2001
Publisher: NISCAIR-CSIR, India
Abstract: As a part of a composite programme of rational drug design (RDD)1, we had synthesized some substituted benzene sulphonyl glutamines and evaluated their inhibitory activities against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. Quantitative structure activity relationship (QSAR) studies of these inhibitory activities using Fujita-Ban model as well as Modified Hansch-Fujita model gave excellent correlations (correlation coefficient r = 0.89 and 0.82 respectively). These results could be useful in designing 'lead' compound with potent inhibitory activity on DNA and RNA synthesis and tumour development.
Page(s): 120-123
URI: http://hdl.handle.net/123456789/19810
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.38(1-2) [February-April 2001]

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