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Title: Oxidative burden and antioxidant defense system in polymorphonuclear leukocytes of human lung diseases
Authors: Sharma, Rashmi N
Bhardwaj, A
Behera, D
Khanduja, K L
Issue Date: Apr-2002
Publisher: NISCAIR-CSIR, India
Abstract: Superoxide anion (O2.-) and hydrogen peroxide (H2O2) production was significantly higher in blood neutrophils (PMNs) of patients with lung cancer and non-malignant lung diseases when compared to the controls (p<0.001). Superoxide dismutase (SOD) activity was significantly decreased in PMNs of patients with lung cancer (p<0.00l). Similarly, catalase and glutathione peroxidase (GPx) activities were lower in PMNs of lung cancer patients as compared to non-malignant lung diseases and controls. There was an increase in HMP shunt activity as measured by rate of formation of 14CO2 from [1-14C]-glucose in PMNs of lung cancer patients. Modifications in the antioxidant defense system in PMNs of malignant and non-malignant lung diseases, the changes being more in the malignancy are indicated.
Page(s): 124-129
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections: IJBB Vol.39(2) [April 2002]

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