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Title: Melatonin treatment prevents modulation of cell-mediated immune response induced by propoxur in rats
Authors: Suke, Sanvidhan G
Pathak, Rahul
Ahmed, Rafat S
Tripathi, A K
Banerjee, B D
Keywords: Melatonin
Cell-mediated immune response
Issue Date: Aug-2008
Publisher: CSIR
Abstract: The effect of melatonin, a major secretory product of the pineal gland, in attenuation of propoxur (2-isopropoxy phenyl N-methyl carbamate)-induced modulation of cell- mediated immune (CMI) response was studied in rats. Male Wistar albino rats were exposed to propoxur (a widely used pesticide) orally (10 mg/kg) and/or melatonin (10 mg/kg) orally for 4 weeks. CMI was measured by delayed-type hypersensitivity (DTH), leucocyte and macrophage migration inhibition (LMI and MMI) responses and estimation of cytokines TNF-α and IFN-γ levels. Rats exposed to propoxur for 4 weeks showed significant decrease in DTH, LMI and MMI responses. Propoxur also suppressed TNF-α and IFN-γ production significantly. Administration of melatonin alone caused a significant increase in DTH response. Although there were no changes in the LMI and MMI response, the cytokine levels were significantly increased, as compared to control. Co-administration of melatonin along with propoxur significantly nullified the effect of the pesticide on the CMI response, except DTH and reversed levels of cytokines to near control/normal values. Thus, melatonin treatment considerably attenuated immunomodulation caused by sub-chronic treatment of propoxur in experimental animals.
Page(s): 278-281
ISSN: 0301-1208
Source: IJBB Vol.45(4) [August 2008]

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