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Title: Non-invasive assessment of oxidative capacity in young Indian men and women: A ³¹P magnetic resonance spectroscopy study
Authors: Rana, Poonam
Varshney, Aruna
Devi, M Memita
Kumar, Pawan
Khushu, Subash
Keywords: Gender
Skeletal muscle
Oxidative capacity
Magnetic resonance spectroscopy
Issue Date: Aug-2008
Publisher: CSIR
Abstract: It is generally assumed that men display greater strength and muscle capacity than women. However, previous biochemical and histological studies have shown that men have greater capacity for anaerobic metabolism and women have higher or similar oxidative metabolism. Therefore, in the present study, we estimated oxidative capacity of gastrocnemius muscle and compared in Indian men and women using non-invasive in vivo ³¹P magnetic resonance spectroscopy (MRS). Healthy subjects (8 young males and 9 females, age-matched) performed plantar flexion exercise within a magnet and MRS measurements of inorganic phosphate (Pi), phosphocreatine (PCr), ADP, and pH of the calf muscles were carried out using a 1.5 T whole-body MRI system. PCr values during recovery were fitted to an exponential curve, and oxidative capacity was calculated using rate constant (kPCr), as an index of oxidative phosphorylation. When men and women were compared for different metabolic ratios, ADP, pH, kPCr and oxidative capacity, all parameters turned out to be statistically insignificant. The results showed no gender effect on skeletal muscle oxidative metabolism. The study demonstrated the usefulness of such non-invasive method to indirectly measure the oxidative capacity of the muscle based on PCr recovery
Page(s): 263-268
ISSN: 0301-1208
Source: IJBB Vol.45(4) [August 2008]

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