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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(4) [August 2008] >
| Title: | Modeling studies on phospholipase A₂-inhibitor complexes |
| Authors: | Nirmal, Nithya
Praba, G Om
Velmurugan, D |
| Keywords: | Phospholipase A₂
Inflammation
Acalyphin
Aplysulphurin 1
Chlorogenic acid
Curcumin
Gracilin A
Stigmasterol
Tectoridin
MOE |
| Issue Date: | Aug-2008 |
| Publisher: | CSIR |
| Abstract: | Phospholipase A₂ (PLA₂) is a ubiquitous enzyme that specifically catalyzes hydrolysis of membrane phospholipids to
produce lysophospholipids and free fatty acid, namely arachidonic acid, which provides substrate for eicosanoids
biosynthesis. Thus, the compounds inhibiting PLA₂ have been implicated as potential therapeutic agents in treatment of
inflammation related diseases. Plant and marine organisms serve as sources of compounds that act as potential therapeutic
agents for treatment of various diseases. The present study reveals the relationship between the structure and function of the
medicinally important herbal compounds (acalyphin, chlorogenic acid, stigmasterol, curcumin and tectoridin) and marine
compounds (gracilin A and aplysulphurin A). To understand the binding mechanisms of these compounds, molecular
modeling studies has been performed with Russell’s viper and bovine pancreatic PLA₂ as target molecules using molecular
operating environment (MOE) software. These compounds show favorable interactions with the amino acid residues at the
active site of Russell’s viper and bovine pancreatic PLA₂, thereby substantiating their proven efficacy as anti-inflammatory
compounds and antidotes. |
| Page(s): | 256-262 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.45(4) [August 2008]
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