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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(3) [June 2008] >
| Title: | Hepatoprotective effect of vitamin C on sodium nitrite-induced lipid peroxidation in albino rats |
| Authors: | Krishnamoorthy, P
Sangeetha, M |
| Keywords: | Sodium nitrite
Vitamin C
Lipid peroxidation
Antioxidant
Marker enzymes |
| Issue Date: | Jun-2008 |
| Publisher: | CSIR |
| Abstract: | The possible protective role of vitamin C on liver antioxidant
enzymes of albino rats in sodium nitrite induced lipid
peroxidation (LPO) was investigated. Sodium nitrite and vitamin
C were administered orally through intragastric tube. Sodium
nitrite (300 mg/kg body wt.) significantly increased the LPO and
the activities of liver marker enzymes such as alanine
aminotransferase (ALT), aspartate aminotransferase (AST), acid
phosphatase and lactate dehydrogenase (LDH), and decreased the
activities of antioxidant enzymes such as superoxide dismutase
(SOD), catalase (CAT) and reduced glutathione (GSH) level in
LPO-induced rats; the remarkable changes in the enzyme
activities was due to hepatotoxicity of nitrite. The vitamin C (300
mg/kg body wt.) significantly decreased the LPO level and the
activities of liver enzymes and increased antioxidant enzymes
activities, thus exerts ameliorating effect on sodium nitriteinduced
lipid peroxidation. |
| Page(s): | 206-208 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.45(3) [June 2008]
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