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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(3) [June 2008] >
| Title: | Protein translocation pathways across the inner and outer mitochondrial membranes |
| Authors: | Kaur, Jaspreet
Kaul, Gautam |
| Keywords: | Mitochondria
Translocation
Membrane potential
ATP hydrolysis |
| Issue Date: | Jun-2008 |
| Publisher: | CSIR |
| Abstract: | Mitochondria import different proteins that are encoded by nuclear genes and synthesized in the cytosol. Separate
translocases in inner and outer mitochondrial membranes like TOM, TIM23, TOB/SAM, TIM22 complex facilitate
recognition, import and intramitochondrial sorting of preproteins. Various cytosolic factors as Hsp70 and auxillary factors
assist in targeting these preproteins to their destinations. Also, different protein components in the matrix participate in this
energetically driven translocation process in a reaction that depends upon membrane potential and matrix-ATP. This review
summarizes the present knowledge on import and sorting of mitochondrial precursor proteins with glance on unresolved
questions. |
| Page(s): | 149-156 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.45(3) [June 2008]
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