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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(3) [June 2008] >
| Title: | Host genes that affect progression of AIDS/HIV in India and novel gene therapeutic approaches against HIV |
| Authors: | Sood, Vikas
Rathore, Anurag
Husain, Sajid
Khan, Sohrab
Patra, Shruti
Shankar, Vijay
Kumar, Harsh
Rani, Neha
Bano, Aalia S
Neogi, Ujjwal
Ramachandran, V G
Banerjea, Akhil C |
| Keywords: | HIV-1
CCR5
Polymorphisms
Chemokine receptors
DNA-enzyme
Ribozyme
siRNA
Lentiviral vectors |
| Issue Date: | Jun-2008 |
| Publisher: | CSIR |
| Abstract: | A multitude of host and viral factors play critical role in susceptibility to HIV-1 infection and its subsequent progression
to AIDS. Various host factors involved in HIV-1 infection include the chemokine receptors CCR5, CX3CR1, their ligands,
RANTES, SDF-1 and cytokines like IL-10, IL-4, among others. The CCR5Δ32 allele is the most important genetic factor
known to confer resistance to HIV-1 infection. However, other mutations in CCR5, CX3CR1 and SDF-1 have also been
identified in Indian population. Polymorphisms in DC-SIGN, MHC class-I and II molecules are also known to affect HIV-1
progression. These polymorphisms can be utilized as genetic markers for evaluating disease progression and developing
effective therapeutics. The review also describes the development of anti-viral therapy, involving the use of catalytic nucleic
acids like DNA-enzymes and ribozymes and the expression of ribozymes and si-RNA using lentiviral vectors for stem cell
based anti-HIV therapy. |
| Page(s): | 141-148 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.45(3) [June 2008]
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