NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(3) [June 2008] >


Title: Host genes that affect progression of AIDS/HIV in India and novel gene therapeutic approaches against HIV
Authors: Sood, Vikas
Rathore, Anurag
Husain, Sajid
Khan, Sohrab
Patra, Shruti
Shankar, Vijay
Kumar, Harsh
Rani, Neha
Bano, Aalia S
Neogi, Ujjwal
Ramachandran, V G
Banerjea, Akhil C
Keywords: HIV-1
CCR5
Polymorphisms
Chemokine receptors
DNA-enzyme
Ribozyme
siRNA
Lentiviral vectors
Issue Date: Jun-2008
Publisher: CSIR
Abstract: A multitude of host and viral factors play critical role in susceptibility to HIV-1 infection and its subsequent progression to AIDS. Various host factors involved in HIV-1 infection include the chemokine receptors CCR5, CX3CR1, their ligands, RANTES, SDF-1 and cytokines like IL-10, IL-4, among others. The CCR5Δ32 allele is the most important genetic factor known to confer resistance to HIV-1 infection. However, other mutations in CCR5, CX3CR1 and SDF-1 have also been identified in Indian population. Polymorphisms in DC-SIGN, MHC class-I and II molecules are also known to affect HIV-1 progression. These polymorphisms can be utilized as genetic markers for evaluating disease progression and developing effective therapeutics. The review also describes the development of anti-viral therapy, involving the use of catalytic nucleic acids like DNA-enzymes and ribozymes and the expression of ribozymes and si-RNA using lentiviral vectors for stem cell based anti-HIV therapy.
Page(s): 141-148
ISSN: 0301-1208
Source: IJBB Vol.45(3) [June 2008]

Files in This Item:

File Description SizeFormat
IJBB 45(3) 141-148.pdf622.93 kBAdobe PDFView/Open
 Current Page Visits: 697 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 512883 since 06-Feb-2009  Last updated on 21-Apr-2014Webmaster: nopr@niscair.res.in