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Title: Host genes that affect progression of AIDS/HIV in India and novel gene therapeutic approaches against HIV
Authors: Sood, Vikas
Rathore, Anurag
Husain, Sajid
Khan, Sohrab
Patra, Shruti
Shankar, Vijay
Kumar, Harsh
Rani, Neha
Bano, Aalia S
Neogi, Ujjwal
Ramachandran, V G
Banerjea, Akhil C
Keywords: HIV-1;CCR5;Polymorphisms;Chemokine receptors;DNA-enzyme;Ribozyme;siRNA;Lentiviral vectors
Issue Date: Jun-2008
Publisher: CSIR
Abstract: A multitude of host and viral factors play critical role in susceptibility to HIV-1 infection and its subsequent progression to AIDS. Various host factors involved in HIV-1 infection include the chemokine receptors CCR5, CX3CR1, their ligands, RANTES, SDF-1 and cytokines like IL-10, IL-4, among others. The CCR5Δ32 allele is the most important genetic factor known to confer resistance to HIV-1 infection. However, other mutations in CCR5, CX3CR1 and SDF-1 have also been identified in Indian population. Polymorphisms in DC-SIGN, MHC class-I and II molecules are also known to affect HIV-1 progression. These polymorphisms can be utilized as genetic markers for evaluating disease progression and developing effective therapeutics. The review also describes the development of anti-viral therapy, involving the use of catalytic nucleic acids like DNA-enzymes and ribozymes and the expression of ribozymes and si-RNA using lentiviral vectors for stem cell based anti-HIV therapy.
Page(s): 141-148
ISSN: 0301-1208
Appears in Collections: IJBB Vol.45(3) [June 2008]

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