NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(08) [August 2008] >


Title: Synthesis and biological evaluation of some new 4,5-dihydro-3-(2-aryl-indol-3-yl)-5- (4-chlorophenyl)-N¹-phenylpyrazoles
Authors: Pathak, Vijai Nath
Gupta, Ragini
Gupta, Neetu
Keywords: Indolyl chalcone
2-pyrazoline
Claisen-Schmidt condensation
Grindstone chemistry
Antimicrobial activity
Issue Date: Aug-2008
Publisher: CSIR
Abstract: A facile and clean cyclization of indolylchalcone with phenyl hydrazine in glacial acetic acid occurs to afford 4,5-dihydro-3-(2-arylindol-3-yl)-5- (4-chlorophenyl)-N¹-phenylpyrazoles 5a-e in quantitative yield using 'Grindstone' technique. The results obtained indicate that, unlike classical heating, grinding method results in higher yields, shorter reaction time and cleaner reaction conditions. All the synthesized compounds have been characterized by their elemental analyses and spectral data (IR, ¹H NMR). Antibacterial and antifungal activity of all synthesized compounds have also been evaluated and some of them show promising results against E. coli, S. aureus, C. albicans and A. niger.
Page(s): 1303-1307
ISSN: 0376-4699
Source:IJC-B Vol.47B(08) [August 2008]

Files in This Item:

File Description SizeFormat
IJCB 47B(8) 1303-1307.pdf172.36 kBAdobe PDFView/Open
 Current Page Visits: 577 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 603853 since 06-Feb-2009  Last updated on 21-Oct-2014Webmaster: nopr@niscair.res.in