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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(08) [August 2008] >
| Title: | Synthesis and biological activities of new hydroxy-3-pyrazolyl-4H-chromen-4-ones and their O-glucosides |
| Authors: | Hatzade, K M
Taile, V S
Gaidhane, P K
Haldar, A G M
Ingle, V N |
| Keywords: | Chromones
Pyrazoles
Glucopyranosyl bromide
Glucosylation
O-β-D-glucosides
Deacetylation
Biological activity |
| Issue Date: | Aug-2008 |
| Publisher: | CSIR |
| Abstract: | The synthesis of a number of 7-hydroxy-3-pyrazolyl-chromen-4H-ones and their O-glucosides has been described. 7-Hydoxy-3-formyl chromen-4H-one 1 on condensation with substituted acetophenones in the presence of piperidine in dry alcohol affords 7-hydroxy-3-(3-oxo-3-arylprop-1-enyl)-4H-chromen-4-ones 2 which on cyclization with phenyl hydrazine hydrochloride leads to the formation of 7-hydroxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl)-4H-chromen-4-ones 3. 7-O-β-D-Glucopyranosyloxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl)-4H-chromen-4-ones 5 have been synthesized by the reaction of 2, 3, 4, 6-tetra-O-acetyl-⍺-D-glucopyranosyl bromide with potassium salt of 3 followed by deacetylation with Zn(CH₃COO)₂ in absolute methanol. Some of the newly synthesized compounds have been screened for their antimicrobial and antioxidant activity. |
| Page(s): | 1260-1270 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(08) [August 2008]
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