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IJC-B Vol.47B(08) [August 2008] >


Title: Synthesis of various heterocycles using coumarinyl isothiocyanates
Authors: Mayekar, Sagar A
Mulwad, Vinata V
Keywords: 6-aminocoumarin
Quinazolinone
Thiohydatoins
Thiazolidinone
Benzooxazole
Benzothiazole
Antimicrobial activity
Issue Date: Aug-2008
Publisher: CSIR
Abstract: Coumarinyl isothiocyanates 2a-c are obtained from 6-amino coumarins 1a-c used as a starting materials for the construction of heterocycles. 6-Coumarinyl isothiocyanate on treatment with anthranilic acid, glycine, thioglycolic acid, o-aminophenol, o-aminothiophenol separately yielded 3-(2-oxo-2H-benzopyran-6-yl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 3a-c, 3-(2-oxo-2H-benzopyran-6-yl)-2-thioxo-imidazolidin-4-one 4a-c, 3-(2-oxo-2H-benzopyran-6-yl)-2-thioxo-thiazolidin-4-one 5a-c, 6-(benzooxazol-2-ylamino)-benzopyran-2-one 6a-c and 6-(benzothiazol-2-ylamino)-benzopyran-2-one 7a-c respectively. The structures of all the compounds are confirmed on the basis of spectral and analytical data. All the above compounds are screened for their antimicrobial activities and some of them have found to show significant antimicrobial activity.
Page(s): 1254-1259
ISSN: 0376-4699
Source:IJC-B Vol.47B(08) [August 2008]

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