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Title: Alterations of phosphatidylinositol signal transduction pathway in hepatic mitochondria following aflatoxin B1 administration*
Authors: Pasupathy, K
Krishna, M
Bhattacharya, R K
Issue Date: Sep-1999
Publisher: NISCAIR-CSIR, India
Abstract: A single dose of aflatoxin B1 (7mg/kg body wt) to male rats significantly stimulated the turnover of mitochondrial phosphoinositides 1-7 hr following its administration. The elevation of phosphatidylinositol 3,4,5-trisphosphate was most pronounced whose level continued to be moderately high even at 17 hr period. The level of diacylglycerol showed a marked increase from 4hr till 7hr after carcinogen treatment, whereas that of inositol 1,4,5-trisphosphate recorded an increase with a maximum at 7 hr foil wed by a gradual decrease to near normal level at 24 hr period. The activation of phosphatidylinositol cycle together with an activation of PI 3-kinase, whose product PIP3 is known to be involved in apoptosis might contribute to the early step in the manifestation of toxicity and/or carcinogenicity.
Page(s): 876-880
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections: IJEB Vol.37(09) [September 1999]

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