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Title: Potentiality of tricyclic compound thioridazine as an effective antibacterial and antiplasmid agent
Authors: Radhakrishnan, V
Ganguly, Kumkum
Ganguly, Manju
Dastidar, Sujata G.
Chakrabarty, A N
Issue Date: Jul-1999
Publisher: NISCAIR-CSIR, India
Abstract: Thioridazine (Th), which is therapeutically used in psychiatric patients, was found to possess conspi-cuous antimicrobial activity when tested against 316 strains belonging to a number of Gram positive and Gram negative bacteria. Although Staphylococcus aureus, Vibrio cholerae and V. parahaemolyticus were found to be most sensitive, Th was highly bactericidal against S aureus and bacteriostatic for vibrios and other Gram negative organisms. In the study of antiplasmid/curing effect of Th on twelve multiply antibiotic and Th resistant bacteria, it was observed that elimination of R plasmids was facilitated by choice of optimal concentration of Th. Significant elimination of single and combined antibiotic resistances occurred in E. coli and Shigella flexneri and not in S.aureus.
Page(s): 671-675
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.37(07) [July 1999]

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