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Title: Molecular mechanics aided design of antineoplastic agents from ruthenium coordinate complexes
Authors: Mazumder, U K
Gupta, M.
Mukherjee, A.
Mukhopadhyay, D.K.
Dey, P.
Issue Date: Jul-1999
Publisher: NISCAIR-CSIR, India
Abstract: Through energy minimization using molecular mechanics force field four ruthenium cordinate complexes have been synthesized. Compound I to IV showed antineoplastic activity with varying degree on EAC bearing mice. Mode of action may be through inhibition of antioxidant property of tumor cell as evident from lipid peroxidase activity. Among the complexes Bis pyridine tetrachloro ruthenium exhibits highest order of activity with respect to increase mean survival time, inhibition of tumour volume, total blood count, hemoglobin and lipid peroxidase activity.
Page(s): 667-670
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.37(07) [July 1999]

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