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Title: Inhibitory effect of piceatannol, a protein tyrosine kinase inhibitor, on asexual maturation of Plasmodium falciparum
Authors: Mishra, Neerad C
Sharma, Manju
Sharma, Arun
Issue Date: Apr-1999
Publisher: NISCAIR-CSIR, India
Abstract: This report describes the effect of piceatannol (3,4,3' ,5' -tetrahydroxy trans stilbene), a plant secondary natural product, on protein tyrosine kinase (PTK) activity in different stages of P. falciparum grown in vitro. Piceatannol inhibited PTK activity in trophozoites and schizonts suggesting that PTK may be important in the initial asexual maturation of the parasite. Inhibition of PTK activity by piceatannol may thus provide new insights into more specific tools for chemotherapeutic interventions for P. falciparum.
Page(s): 418-420
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.37(04) [April 1999]

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