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|Title:||Does TAME induced contraction involve an endothelium dependent nitric oxide-cyclic GMP mediated pathway?|
|Authors:||Subratty, A H|
|Abstract:||Two enzyme inhibitors namely L-NAME, a nitric oxide synthase (NOS) inhibitor and methylene blue, a guanylate cyclise inhibitor, were used to elucidate whether N-α-tosyl L-arginine methyl ester (TAME)-induced contract ions in toad intestinal rings in vitro are mediated through a nitric oxide (NO)- cyclic GMP (c-GMP) pathway. Moreover, a NO precursor, L-arginine was also used to investigate its effect on TAME-induced contractions. Our findings provide evidence that TAME-induced contractions have both an endothelium-dependent and an endothelium-independent component. Based on our findings we now propose that TAME induced contraction involves an endothelium-dependent component mediated through NO and c-GMP.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.37(04) [April 1999]|
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