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Title: Progesterone potentiating effect of Dipsacus mitis D. Don for its contraceptive action in hamster*
Authors: Kitchlu, Shakti
Mehrotra, P.K.
Singh, Sumitra
Issue Date: Apr-1999
Publisher: NISCAIR-CSIR, India
Abstract: A pure compound, isolated from ethyl acetate extract (root) of D. mitis D. Don, prevented pregnancy by 100% in adult female hamster but partially in rat when administered orally on Days 1-7 and 1- 10 post-coitum respectively. The effective dose in both species was 150 mg/kg. Using uterine wet weight in ovariectomized immature rat as bioassay method, the .compound was found to be devoid of estrogenic and antiestrogenic property. On examination for progestational and antiprogestational activity, using trauma-induced deciduoma formation in immature rat uterus as end points, the compound (per se) did not show the former activity but in a conjoint treatment with progesterone it augmented the act ion of latter. The compound was assumed to act by potentiating progesterone biosynthesis, the excess of which might be the cause for interruption of pregnancy in hamster. This is the first study to report. contraceptive efficacy and mode of its action at the uterine level.  
Page(s): 402-405
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.37(04) [April 1999]

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