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|Title:||Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats|
Bhargava, V K
|Abstract:||The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate. The median effective dose [ED50] of valproate, nimodipine and nitrendipine were initially determined. All the 3 drugs were injected ip 30 min before the induction of seizures. Seizures were induced by PTZ 85mg/kg ip, and subsequently the effect of combining ED50 doses of nimodipine and nitrendipine with ED50 dose of valproate was evaluated. ED50 of valproate and nitrendipine were 129 and 2.5 mg/kg respecti vely. ED50 of nimodipine could not be established since a dose-response relationship was not obtained. Hence, for the purpose of combination studies, 4mg/kg of nimodipine was used. Both nimodipine (4mg/kg) and nitrendipine (2.5mg/kg) decreased the ED50 of valproate from 129 to 40mg/kg. Both nimodipine and nitrendipine potentiate the activity of valproate against PTZ induced seizures and can be considered as potential adjuvant anticonvulsants which merit further study.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.37(04) [April 1999]|
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