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Title: Mast cell stabilizing and lipoxygenase inhibitory activity of Cedrus deodara (Roxb.) Loud. wood oil
Authors: Shinde, U A
Kulkarni, K R
Phadke, A S
Nair, A M
Mungantiwar, A A
Dikshit, V J
Saraf, M N
Issue Date: Mar-1999
Publisher: NISCAIR-CSIR, India
Abstract: Volatile oil of C. deodara, administered orally at the doses of 50, 100 and 200 mg/kg body weight, significantly inhibited the pedal edema induced by compound 48/80 in rats. The oil significantly inhibited compound 48/80 induced degranulation of isolated rat peritoneal mast cells at concentrations ranging from 25-200 μg / ml. C. deodara wood oil also significantly inhibited th e enzyme lipoxygenase at a concentration of 200 μg/ ml. Thus, the anti -inflammatory activity of C. deodara wood oil could be attributed to its mast cell stabilizing activity and the inhibition of leukotriene synthesis.
Page(s): 258-261
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.37(03) [March 1999]

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