Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/18989
Title: Release of iron from haemoglobin-A possible source of free radicals in diabetes mellitus
Authors: Kar, Manoj
Chakraborti, Abhay Sankar
Issue Date: Feb-1999
Publisher: NISCAIR-CSIR, India
Abstract: In creased blood glucose in diabetes mellitus stimulates nonenzymatic glycosylation of several proteins, including haemoglobin. Although iron is tightly bound to haemoglobin, it is liberated under specific circumstances yielding free reactive iron. Studies with purified haemoglobin from normal individuals and diabetic patients revealed that concentration of free iron was significantly higher in the latter cases and increased progressively with extent of the disease. In vitro glycosylation of haemoglobin also led to increase in release of iron from protein . This increase in free iron, acting as a Fenton reagent, might produce free radicals, which, in turn might be causing oxidative stress in diabetes.
Page(s): 190-192
URI: http://hdl.handle.net/123456789/18989
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.37(02) [February 1999]

Files in This Item:
File Description SizeFormat 
IJEB 37(2) 190-192.pdf596.76 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.