Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/18802
Title: Synthesis and antiviral activity of furobenzopyrones
Authors: Pandey, V K
Singh, V K
Tandon, M
Joshi, M N
Bajpai, S K
Issue Date: Aug-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 D 311/04 // A 61 P 31/12
Abstract: p-Phenylacetophenone 1 is synthesized by Friedel-Crafts acylation of diphenyl. Bromination of 1 in gl. acetic acid affords p-phenyl phenacyl bromide 2, which on reaction with 7-hydroxy-4-methyl coumarin (4-methyl umbellifcrone) has resulted in 4-methyl-7-(4'-phenylphenacyloxy)-benzo [1,2-b] pyran-2-one 3. Reaction of 3 with phosphorusoxychloride in carbon tetrachloride gives a cyclized product 2H-4-methyl-9-(p-phenyl-phenyl)-furo-[2',3',5,6]-benzo[1,2-b]pyran -2-one 4, which on treatment with aromatic aldehydes yields 2H-4-styryl-9-[p-phenyl-phenyl)-furo-[2' ,3',5,6]-benzo-[1,2-b] pyran-2- ones 5. Compounds 5 are evaluated for their antiviral activity against Japanese encephalitis virus (JEV) and Herpes simplex virus type-I (HSV-I).
Page(s): 1770-1773
URI: http://hdl.handle.net/123456789/18802
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(08) [August 2004]

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