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Title: Screening of natural products for new leads as inhibitors of IκBα kinase: Coumarin derivatives from plant extracts
Authors: Ramakrishna, N V S
Kulkarni, A S
More, T S
Bhat, R G
Krishnamurthy, S
DeSouza, E P
Vijayakumar, E K S
Gupte, R D
Vadlamudi, R V S V
Issue Date: Apr-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 D 311/10
Abstract: Mammea A/AB 1, Mammea A/AD 2, 1ʹʹʹ-acctoxy-mammca E/BB 3 and Mammea A/BB 4 have been isolated by bioactive purification. Compounds 1 and 2 are isolated from CH2Cl2 MeOH (1:1) extract of fruits of Mammea suriga and 3 is isolated from the same solvent extraction of twigs. 4 is isolated from methanol extract of leaves of Mesua ferrea. All the four compounds 1, 2,3 and 4 exhibit interesting IκBα kinase inhibitory activity.
Page(s): 869-872
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.43B(04) [April 2004]

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