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Title: Synthesis and insecticidal activity of some 1,3,4-oxadiazoles derived from 2-chloropyridine-5-acetic acid
Authors: Holla, B Shivarama
Prasanna, C S
Poojary, Boja
Rao, K S
Shridhara, K
Bhat, U Ganesha
Issue Date: Apr-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 D 271/10 // A 01 N 43/72
Abstract: The synthesis of a number of 1,3,4-oxadiazoles 6a-e is described . 2-Chloropyridine-5-aeetic acid 3 is prepared starting from easily available 2-chl oro-5-chloromethylpyridine 1, via 2-chloro-5 -cyanomethylpyridine 2. Esterification of 3 with methanol in the presence of H2SO4 gives the corresponding methyl ester 4. Hydrazinolysis of 4 with hydrazin hydrate affords 2-chloropyridine-5-acetic acid hydrazide 5. Hydrazide 5 on reacting with aroyl chlorides in the presence of POCl3 yields 2-chloro-5 -(5-aryl-1 ,3,4-oxadiazol-2 -yl)methylpyridines 6a-c.
Page(s): 864-868
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.43B(04) [April 2004]

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