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Title: Simple and efficient synthetic routes to s-triazinyl dithiocarbamate derivatives: 2,4-Diary lamino-6-[N -(4' -ethoxyphenyl)dithiocarbamoyl] -s-triazines and 2,4-bis[N-(4' -ethoxyphenyl)dithiocarbamoyl] -6-arylamino-s-triazines
Authors: Desai, R M
Ravat, N R
Shah, V H
Issue Date: Feb-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 D 251/12, C 07 C 333/00
Abstract: Compounds 2,4-diary lamino-6-[N -(4' -ethoxyphenyl)dithiocarbamoyl] -s-triazines 4a-f and 2,4-bis-[ N-(4'-ethoxyphenyl) dithiocarbamoyl]-6-arylamino-s-triazines 7a-f have been synthesized by two different methods. In the first method (A) of preparation, 2,4,6-trichloro-s-triazine 1 is condensed with N-(4-ethoxyphenyl)ammoniumdithiocarbamate to afford 3 or 6 followed by the reaction with arylamines to afford 4a-f or 7a-f. In the second method (B) of preparation, 1 is condensed with arylamines to yield 2a-f or 5a-f followed by the action of N-(4-ethoxyphenyl) ammoniumdithiocarbamates to yield 4a-f or 7a-f. The constitutions of newly synthesised compounds 4a-f and 7a-f have been established on the basis of elemental analyses, IR and PMR spectral data. Antimicrobial activity of compounds 4a-f and 7a-f are performed by using cup-plate method against gram-positive bacteria, gram-negative bacteria and antifungal fungi. All the synthesised compounds have shown significant antimicrobial activity.
Page(s): 367-373
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(02) [February 2004]

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