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|Title:||Thiadiazolyl quinazolones as potential antiviral and antihypertensive agents|
|Authors:||Pandey, V K|
Joshi, M N
Bajpai, S K
|Abstract:||Phthalic anhydride on treatment with β-ethanol amine gives N-hydroxy ethyl phthalimide I which reacts with anthranilic acid in presence of ethanol containing concentrated hydrochloric acid affording 5-(N-ethylphthalimido)-anthranilic acid 2. This on treatment with benzoyl chloride in pyridine gives 6-(N-ethyl phthalimido)-2-phenyl-4-oxo-3, 4-dihydrobenzoxazine 3 which on reaction with 2-amino-5 -aralkyl -1 , 3, 4-thiadiazoles 4 in pyridine results in the format ion of 6-(N-ethylphthalimido)-3- [2'-(5'-aralkyl-1', 3', 4'-thiadiazolyl)]-2 - phenyl-4-oxo-(3H)-quinazolines 5. The antiviral and antihypertensive activities of 5 have been reported.|
|Appears in Collections:||IJC-B Vol.43B(01) [January 2004]|
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