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Title: Thiadiazolyl quinazolones as potential antiviral and antihypertensive agents
Authors: Pandey, V K
Tusi, Sarah
Tusi, Zehra
Raghubir, R
Dixit, M
Joshi, M N
Bajpai, S K
Issue Date: Jan-2004
Publisher: NISCAIR-CSIR, India
Abstract: Phthalic anhydride on treatment with β-ethanol amine gives N-hydroxy ethyl phthalimide I which reacts with anthranilic acid in presence of ethanol containing concentrated hydrochloric acid affording 5-(N-ethylphthalimido)-anthranilic acid 2. This on treatment with benzoyl chloride in pyridine gives 6-(N-ethyl phthalimido)-2-phenyl-4-oxo-3, 4-dihydrobenzoxazine 3 which on reaction with 2-amino-5 -aralkyl -1 , 3, 4-thiadiazoles 4 in pyridine results in the format ion of 6-(N-ethylphthalimido)-3- [2'-(5'-aralkyl-1', 3', 4'-thiadiazolyl)]-2 - phenyl-4-oxo-(3H)-quinazolines 5. The antiviral and antihypertensive activities of 5 have been reported.
Page(s): 180-183
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(01) [January 2004]

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