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Title: Copper(II) promoted hydrolysis of 2,4,6-tris(2-pyridyl)-1,3,5-triazine: Synthesis, characterization and biological activities of the hydrolytic products
Authors: Patel, Ram N
Sondhiya, Vishnu P
Patel, Dheerendra K
Shukla, Krishna K
Patel, Dinesh K
Singh, Yogendra
Keywords: Coordination chemistry;X-ray crystal structure;Bifurcated hydrogen bonding;Hydrogen bonding;EPR spectroscopy;DNA cleavage;Copper;Triazines
Issue Date: 5-Jun-2013
Abstract: The hydrolysis of 2,4,6-tris(2-pyridyl)-1,3,5-triazine (tptz) yield the compounds bis(2-pyridylcarbonyl)amide and 2-picolinamide. From these hydrolytic products, two copper(II) complexes viz,. [Cu(IDA)(2-pa)].2H2O (1) and [Cu(bpca)(H2O)2]NO3.2H2O (2) [where IDA = iminodiacetic acid, 2-pa = 2-picolinamide and bpca = bis(2-pyridyl-carbonyl)amido] have been isolated and structurally characterized by single crystal X-ray diffraction studies. Both complexes belong to the triclinic crystal system having space group P-1. Complex (2) shows significant hydrogen bonding and non-covalent ππ stacking interactions. In complex (2), Bifurcated (three centered) hydrogen bonds have been detected. The electron paramagnetic mononuclear copper(II) complexes display X-band epr spectra in 100% DMSO at 77 K giving g > g   > 2.0023, indicating dx2-y2 ground state in a square pyramidal geometry. In-vitro antibacterial study has been assayed against some selected microorganisms using agar disc diffusion method. The DNA cleavage activities of both complexes are also investigated by gel electrophoresis using pBR 322 DNA.
Page(s): 717-723
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.52A(06) [June 2013]

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