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Title: Promoters, toll like receptors and microRNAs: A strange association
Authors: Korla, Kalyani
Arrigo, Patrizio
Mitra, Chanchal K
Keywords: Toll like receptor;miRNA;Promoter;microRNA;Transcription
Issue Date: Jun-2013
Publisher: NISCAIR-CSIR, India
Abstract: Toll-like receptors (TLRs) are proteins that play key role in the innate immune system. In the present study, ~1000 base pairs upstream are taken from the transcription start site of the various TLR genes (10 known) in human. About 40 microRNAs have been identified that share 12-19 nucleotide sequence similarity with the promoter regions of 10 TLRs. It is proposed that the microRNA performs potential role in identification of promoter sequence and initiation of transcription.
Page(s): 169-176
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.50(3) [June 2013]

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