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Title: Formation constants and molecular modelling studies on interaction of metal ions with 6- f1uoro-7-(5-nonyl-1 ,3,4-oxadiazol-2-ylsulphanyl)-4-quinolone-3-carboxylic acid [QDA]
Authors: Sharma, R K
Chopra, Shilpa
Kidwai, M
Issue Date: Nov-2001
Publisher: NISCAIR-CSIR, India
Abstract: Formation constants of Cu, Ni , Co, Zn, Mn and Mg with 6-fluoro- 7 -(S-nonyl- I ,3,4-oxadiazol-2-y Isulphanyl)-4-quinolone-3- carboxylic acid have been determined using BEST program. Species distribution is plotted using programs BEST and SPE which indicates that at biological pH value, complex formation is taking place with Mg. Molecular mechanics calculations also confirm the complexation behaviour of the ligand . This supports the explanation of antibacterial mechanism through complexation of drug with Mg of bacterial DNA.
Page(s): 1240-1242
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.40A(11) [November 2001]

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