Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/18300
Title: Prediction of chiral separation of ketoprofen using experimental design
Authors: Valliappan, K
Kannan, K
Manavalan, R
Muralidharan, C
Issue Date: Jul-2002
Publisher: NISCAIR-CSIR, India
Abstract: The paper demonstrates how experimental design could be applied to predict chiral resolution and run time for indirect chiral high performance liquid chromatography (HPLC) analysis of ketoprofen. An attempt is made to establish quantitative relationship between chromatographic variables and the response factors (resolution and retention time). The effects of important chromatographic variables on chiral resolution and retention time have been highlighted by way of interaction studies. This technique enables optimal utilization of resources by avoiding trial and error approach. The study advocates that experimental design is a prospective tool to predict and optimize chromatographic conditions for chiral HPLC analysis.
Page(s): 1334-1340
URI: http://hdl.handle.net/123456789/18300
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.41A(07) [July 2002]

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