NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.07 [2008] >
IJBT Vol.07(2) [April 2008] >


Title: Comparison of nucleotide and amino acids sequence of Nilgai (Boselaphus tragocamelus) interleukin-18 (IL-18) with other ruminants
Authors: Das, Dhanjit Kumar
Saini, Mohini
Swarup, Devendra
Gupta, Praveen Kumar
Keywords: inerleukin-18
Boselaphus tragocamelus
Cloning
cDNA sequence
Nilgai
Issue Date: Apr-2008
Publisher: CSIR
Abstract: Interleukin-18, a component of innate immunity with potent interferon-ϒ-inducing activity, is not well characterized in wild ruminants. In this study, IL-18 cDNA of Nilgai (Boselaphus tragocamelus) was cloned and characterized. The nucleotide sequence was 582 bp long and contained its entire open reading frame encoding 193 amino acid residues. The sequence analysis indicated seven nucleotide substitutions with reported buffalo sequence showing 98.5% similarity, 97.8% with cattle and 97.6% with sheep. The Nilgai IL-18 cDNA included a putative cleavage site of IL-1β-converting enzyme (ICE) and IL-1 signature-like sequence identified in human and cat IL-18 cDNA. Both nucleotide as well as amino acid sequence similarity shows that the cloned sequence was closer to buffalo IL-18 sequence.
Page(s): 195-199
ISSN: 0972-5849
Source: IJBT Vol.07(2) [April 2008]

Files in This Item:

File Description SizeFormat
IJBT 7(2) 195-199.pdf1.11 MBAdobe PDFView/Open
 Current Page Visits: 592 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 625071 since 06-Feb-2009  Last updated on 28-Nov-2014Webmaster: nopr@niscair.res.in