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|Title:||Green synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(4-fluorophenyl)-1,8-naphthyridin-2-yl]pyrazoles|
Chandra, A Vinay
|Keywords:||1,8-Naphthyridine;Pyrazole;Vilsmeier-Haack reagent;Solid support;Microwave irradiation;Antibacterial activity|
|Abstract:||An efficient and convenient method for the synthesis of 3-aryl-4-formyl-1-[3-(4-fluorophenyl)-1,8-naphthyridin-2-yl]-pyrazoles 4 from acetophenone 3-(4-fluorophenyl)-1,8-naphthyridin-2-ylhydrazones 3 is achieved using POCl3-DMF over silica gel under microwave irradiation. The structural assignments of compounds 3 and 4 are based on their elemental analyses and spectral (IR, 1H NMR and MS) data. The compounds 4 have been screened for their antibacterial activity.|
|Appears in Collections:||IJC-B Vol.52B(05) [May 2013]|
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