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Title: Green synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(4-fluorophenyl)-1,8-naphthyridin-2-yl]pyrazoles
Authors: Mogilaiah, K
Chandra, A Vinay
Srivani, N
Praveena, D
Keywords: 1,8-Naphthyridine;Pyrazole;Vilsmeier-Haack reagent;Solid support;Microwave irradiation;Antibacterial activity
Issue Date: May-2013
Publisher: NISCAIR-CSIR, India
Abstract: An efficient and convenient method for the synthesis of 3-aryl-4-formyl-1-[3-(4-fluorophenyl)-1,8-naphthyridin-2-yl]-pyrazoles 4 from acetophenone 3-(4-fluorophenyl)-1,8-naphthyridin-2-ylhydrazones 3 is achieved using POCl3-DMF over silica gel under microwave irradiation. The structural assignments of compounds 3 and 4 are based on their elemental analyses and spectral (IR, 1H NMR and MS) data. The compounds 4 have been screened for their antibacterial activity.
Page(s): 698-701
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(05) [May 2013]

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