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Title: Synthesis of salidroside analogues and their ability of DPPH radical scavenging activity
Authors: Zheng, Cheng
Guo, Yibing
Meng, Ying
Dou, SuFeng
Shao, Jian
Yang, YuMin
Keywords: Salidroside;Analogues;Koenigs-Knorr method;DPPH
Issue Date: May-2013
Publisher: NISCAIR-CSIR, India
Abstract: Salidroside is a phenylpropanoid glycoside isolated from Rhodiolarosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 22 novel glycosides have been synthesized and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenge activity of each glycoside has been evaluated. 2-(3,4,5-Trihydroxyphenyl)ethyl β-d-galactopyranoside and 3-(3,4,5-trihydroxyphenyl)propyl β-d-glucopyranoside exhibit significant activity prior to salidroside and Vitamin C with EC50 values of 35.85 µM and 36.71 µM, respectively. The results indicate that the phenolic hydroxyl group of these compounds is important for radical scavenging activity and phenyl ring substitution by electron-donating substituents lead to increased antioxidant activity.
Page(s): 654-664
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(05) [May 2013]

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