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|Title:||Design and Evaluation of An Oral Controlled Release Microparticulate Drug Delivery System of Nimesulide by Ionotropic Gelation Technique and Statistical Optimization by Factorial Analysis|
Ghosh, L K
Gupta, B K
|Abstract:||An attempt was made to prepare aqueous solvent based micropelletization of nimesulide by ionotropic gelation technique, with a view to deliver the drug at sustained manner in the gastro-intestinal tract and consequently into the systemic circulation. Present method being aqueous solvent based, it eliminates the problems and hazards associated with the organic solvent. Two types of micropellets were prepared; one batch was prepared with sodium alginate and other batches were prepared with sodium alginate and hydroxypropyl methylcellulose (HPMC) using calcium chloride as counter ion solution. Prepared micropellets were spherical and free flowing. These micropellets were subjected to different physico-chemical evaluation, dissolution and continuous pH dissolution study, which gave satisfactory results. Micropellets prepared with sodium alginate were capable of sustaining the action for 5-6 h and those prepared with both sodium alginate and HPMC were capable of sustaining action for 8 h. Finally statistical optimization was done with two-way analysis of variance (ANOVA) and linear regression analysis.|
|ISSN:||0975-1084 (Online); 0022-4456 (Print)|
|Appears in Collections:||JSIR Vol.58(09) [September 1999]|
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