Please use this identifier to cite or link to this item:
http://nopr.niscair.res.in/handle/123456789/1765
Title: | Synthesis and cytotoxicity studies of thiazole analogs of the anticancer marine alkaloid dendrodoine |
Authors: | Reji, T F Abbs Fen Devi, S K C Thomas, K K Sreejalekshmi, K G Manju, S L Francis, M Philip, S K Bharathan, A Rajasekharan, K N |
Keywords: | Dendrodoine;Marine alkaloid;Thiazole analog;2-aminothiazole;Cytotoxicity |
Issue Date: | Jul-2008 |
Publisher: | CSIR |
Abstract: | The synthesis and cytotoxicity evaluation of 2-N,N-dimethylamino-5-indol-3-oylthiazole as the first member of a new portfolio of the thiazole analogs of the cytotoxic marine alkaloid dendrodoine (3-N,N-dimethylamino-5-indol-3-oyl-1,2,4-thiadiazole) is described. Exploiting the opportunity arising from the replacement of the thiadiazole ring of dendrodoine by a thiazole ring which allowed further substitution on the five-membered ring, 2-N,N-dimethylamino-5-indol-3-oyl-4-phenylthiazole has also been synthesized. Structural diversity is further extended by synthesizing 5-fur-2-oyl- and 5-coumarin-3-oyl-2-N,N-dimethylaminothiazoles, as well as 5-fur-2-oyl, 5-thiophen-2-oyl, 5-(1-methylbenzimidazol-2-oyl) and 5-benzothiazol-2-oyl derivatives of 2-N,N-dimethylamino-4-phenylthiazoles. Among these new N,N-dimethylaminothiazoles, 2-N,N-dimethylamino-5-indol-3-oyl-4-phenylthiazole shows significant in vitro cytotoxicity against a panel of human cancer cell lines. |
Page(s): | 1145-1150 |
URI: | http://hdl.handle.net/123456789/1765 |
ISSN: | 0376-4699 |
Appears in Collections: | IJC-B Vol.47B(07) [July 2008] |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
IJCB 47B(7) 1145-1150.pdf | 140.58 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.