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dc.contributor.authorDesai, N C-
dc.contributor.authorShah, M D-
dc.contributor.authorBhavsar, A M-
dc.description.abstractSeveral 2-(4-chlorophenyl)-N-(4-oxo-2-aryl(l,3,thiazolidin-3-yl))acetamides 2, N-[3-chloro-4-(2-aryl)-2-oxo-azetidinyl]-2-(4-chlorophenyl)acetamides 3, N-(4-oxo-2-aryl(1,3,-thiadiazolidin-3-yl){4-[5-oxo-2-phenyl-4-(phenylmethylene) (2-imidazolinyl)phenyl}carboxamides 7 and N-(3-chloro-2-oxo-4-arylazetidinyl){4-[5-oxo-2-phenyl-4-(phenylmethylene)(2-imidazolinyl)] phenyl}carboxamides 8 have been synthesized and evaluated for their antibacterial activity against gram +ve and gram -ve bacteria i.e. S. aureus and E. coli. Most of the compounds are showed moderate to good activity against gram +ve and gram -ve bacteria. The QSAR studies of these compounds have been carried out in terms of structural and physicochemical parameters where positive contribution of substituents present at position-3 of N-[3-chloro-4-(2-aryl)-2-oxo-azetidinyl]-2-(4-chlorophenyl)acetamides with bulkier group indicating increase in hydrophobicity or steric bulk character.en_US
dc.sourceIJCB Vol.47B(7) [July 2008]en_US
dc.subjectAntibacterial activityen_US
dc.subjectLinear free energy relationship (LFER)en_US
dc.subjectQSAR studyen_US
dc.titleSynthesis and QSAR studies of 4-oxo-thiazolidines and 2-oxo-azetidines as potential antibacterial agentsen_US
Appears in Collections:IJC-B Vol.47B(07) [July 2008]

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